1998-2023 Mayo Foundation for Medical Education and Research (MFMER). It is important to take the drug at the same times each day. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. In: Current Medical Diagnosis & Treatment 2022. Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. Higher dosages are associated with stomach irritation and 88 ratings on Drugs.com. . As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. All rights reserved. Isosorbide-2,5-dinitrate and isosorbide-5-mononitrate, the low-potent organic nitrates, are directly metabolized in the endoplasmic reticulum of the vascular smooth muscle cells via cytochrome P450 enzymes, resulting in direct production of nitric oxide (Mnzel et al., 2005).In contrast, the highly potent organic nitrates such as glyceryl trinitrate (GTN) and pentaerythritile tetranitrate . Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Natural Medicines. Accessed Sept. 7, 2022. Advertising revenue supports our not-for-profit mission. Accessed Sept. 7, 2022. Dated August 2017. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. This is so your doctor can check on your progress. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. All rights reserved. Do not store in the bathroom. These side effects may go away during treatment as your body adjusts to the medicine. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Normal ecg doesn't rule out heart disease. Generic alternatives may be available. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. This product is available in the following dosage forms: There is a problem with Side effects : headache, mild dizziness Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Before Elsevier; 2021. https://www.clinicalkey.com. Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. We don't support your browser. This should pass after a few days. Natural Medicines. Integrative medicine (complementary and alternative medicine). A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. See the full pregnancy warnings document. Imdur vs. Isordil - RxList Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with heart failure. It's usually not a problem for most people unless you drink alcohol or take other medications that can also lower your blood pressure. Talk to your provider if you continue to feel dizzy or have a fast heart rate a week after starting isosorbide mononitrate (Monoket). Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. It can make you really dizzy. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Many herbal supplements can interact with prescription drugs. Other medications may be prescribed by your doctor for these conditions. Cardizem Alternatives Compared - Drugs.com Zhonghua Yi Xue Za Zhi (Taipei). May also be prescribed off label for Esophageal Spasm. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. you should know that you may experience headaches every day during your treatment with isosorbide. It is best not to drink alcohol while you are on isosorbide mononitrate. Drug interactions may change how your medications work or increase your risk for serious side effects. coma (loss of consciousness for a period of time). Unauthorized use of these marks is strictly prohibited. Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease. In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Otherwise, call a poison control center right away. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Things to remember when you fill your prescription. Unable to load your collection due to an error, Unable to load your delegates due to an error. What conditions does Isosorbide Mononitrate treat? Are you looking for information on isosorbide dinitrate (Isordil) instead? This content does not have an English version. Botanical medicine A modern perspective. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. UpToDate It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Evening primrose. AskMayoExpert. Disclaimer. The narrowing makes it more difficult for blood to flow to your heart muscle. This is called a medicine interaction. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Thirty percent of the patients never experienced headache from the given dosages. Isosorbide mononitrate (Monoket) is not a medication you take if you think you are having a heart attack. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. Glyceryl trinitrate (GTN) is commonly prescribed for this. Continue to take isosorbide even if you feel well. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Do not try to change the times or the way that you take isosorbide in order to avoid headaches because then the medication may not work as well. Nitroglycerin has an average rating of If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. 72% of reviewers reported a positive effect, while 12% reported a negative effect. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. If you forget to take a dose, take it as soon as you remember. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. In: Textbook of Natural Medicine. Please note that only the generic name of each medication is listed below. Take the container with you, even if it is empty. Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Isosorbide Mononitrate - Medicine.com Some don't work well with prescription medicines. Aspirin relieves pain and inflammation and helps to thin the blood. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Does Viagra add to the risks of melanoma? There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. If we combine this information with your protected This document does not contain all possible drug interactions. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. That's why you need to talk with your health care provider before you take herbal supplements if you take prescription medicines. Portions of this document last updated: Feb. 01, 2023. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. Take extra precautions to avoid falling during your treatment with isosorbide. This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or . The most common side-effect is headache. https://naturalmedicines.therapeuticresearch.com. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Learn to reduce stress through mindful living. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Use of herbal products and potential interactions in patients with cardiovascular diseases. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. Data were assessed for carryover and time effects. Don't drink alcohol while taking isosorbide mononitrate (Monoket). Accessed Sept. 7, 2022. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure. Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, isosorbide mononitrate consumer information. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Consult your pharmacist or local waste disposal company. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Minimally clinically significant. All rights reserved. Nitrate-induced headache in patients with stable angina pectoris It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. May also be prescribed off label for Esophageal Spasm. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Talk to your doctor if you are using marijuana (cannabis). If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Accessed Sept. 7, 2022. Never take more than the prescribed dose. My cardiologist recommended I get on metropolol. 1994 Jan;15(1):108-13. doi: 10.1093/oxfordjournals.eurheartj.a060361. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. If you have an underactive thyroid gland. A very serious allergic reaction to this drug is rare. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. It is used to treat and prevent a wide range of different conditions. Talk to your doctor about the possible risks of using this medication for your condition. Alcohol or marijuana (cannabis) can make you more dizzy. What special dietary instructions should I follow? Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat. Some conditions may become worse when the drug is suddenly stopped. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Isosorbide may not work as well after you have taken it for some time or if you have taken many doses. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. St. Joseph 81 mg Aspirin Enteric Safety-Coated. On the other hand, the ER version can only help prevent angina. information is beneficial, we may combine your email and website usage information with the unsubscribe link in the e-mail. In case of overdose, call the poison control helpline at 1-800-222-1222. Copyright, 2023. Can isosorbide mononitrate cause problems? and transmitted securely. It is important that you follow the instructions your doctor gives to you about when to take your doses. Isosorbide mononitrate (Monoket) can cause your blood pressure to drop somewhat. . This survey is being conducted by the WebMD marketing sciences department. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking isosorbide. Isosorbide: MedlinePlus Drug Information Isosorbide mononitrate - UpToDate Alcohol can make the side effects from isosorbide worse. Daily headaches are a common side effect. Follow directions about how much medicine to take. from the best health experts in the business. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Take care, thanks. Is it safe to drive while on this medicine? Using this medicine with any of the following medicines is not recommended. Is not subject to the Controlled Substances Act. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. If this worries you, talk to your doctor or pharmacist about other options. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. Change positions slowly until your body is used to the medication. Accessed Sept. 7, 2022. It will not treat an angina attack that has already begun. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. Federal government websites often end in .gov or .mil. . Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). All rights reserved. Isosorbide Mononitrate (Oral Route) - Mayo Clinic Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. Available for Android and iOS devices. If you suffer headaches when taking Isosorbide mononitrate, be patient. It works by . Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Isosorbide mononitrate Interactions - Drugs.com Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Yes, it's good for health but don't take it excesse in amount, use once daily for 1 month then stop it or take once a weekly. Do not stop taking isosorbide without talking to your doctor. This medicine is available only with your doctor's prescription. If you become pregnant while taking isosorbide, call your doctor. In: Current Medical Diagnosis & Treatment 2022. Does Alcohol Raise Your Blood Pressure? Isosorbide mononitrate (Monoket): Basics, Side Effects & Reviews - GoodRx Prescription and OTC you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Accessed Sept. 7, 2022. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. This content does not have an Arabic version. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Important information about all medicines, Notes on Isosorbide mononitrate dose and side-effects info, https://patient.info/medicine/isosorbide-mononitrate-elantan-imdur-isotard-monomax-tardisc-xismox, Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets, Carmil XL; Chemydur XL; Elantan LA; Imdur; Isib XL; Ismo; Isodur XL; Isotard XL; Modisal XL; Monomax SR; Monomil XL; Nyzamac SR; Relosorb XL; Tardisc XL; Trangina XL; Xismox XL; Zemon XL, Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules, Ask your doctor or pharmacist to recommend a suitable painkiller.
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